Showing posts with label CBD. Show all posts
Showing posts with label CBD. Show all posts

Thursday, April 9, 2015


70 known Cannabinoids (8 showing)

Edited and published by Right Reverend Gregory Karl Davis
Cannabinoid therapy appears to works marvelously for some, and yet others fail to respond.
Whilst it is critical to consider cannabinoid content as a factor in this (i.e. – Is there enough Cannabidiol (CBD) in your extract? Etc. Another mitigating detail lies within if ones cannabinoid receptors are activated or not.
Methylation has been proven to deactivate CB receptors, and this appears particularly prevalent within cancers of the stomach, colon1 and breast. If methylation can create such an unwanted and critical scenario during cannabinoid therapy, then those undergoing cannabinoid therapy should look to include demethylating2 agents into their regime.
These include; Green Tea, FeverFew and Annurca Apples3 Green Tea is particularly useful as it can also naturally create Anti-Angiogenesis4
Another area that should be explored is within the use of Phenolic Oils.
Phenols and Phenylpropanoids are compounds of carbon-ring molecules incorporating on isoprene unit. They are sometimes called hemiterpenes. There are dozens of varieties of phenylpropanoids. They are found in Clove (90%), Cassia (80%), Basil (75%), Cinnamon (73%), Oregano (60%), Anise (50%), and Peppermint (25%).
While they can create conditions where unfriendly viruses and bacteria cannot live, the most important function performed by phenylpropanoids is that they clean the receptor sites on the cells. Without clean receptor sites cells cannot communicate, and the body malfunctions, resulting in sickness.
David Stewart, PhD, DNM also suggests in his book 'The Chemistry of Essential Oils Made Simple’ – that phenolic oils can clean receptor sites.
Prof. Dr. Jürg Gertsch of the Institute of Biochemistry and Molecular Medicine, Switzerland conducted a brilliant research paper5 looking for Phytocannabinoids beyond cannabis.
Prof Jürg Gertsch was kind enough to suggest the essential oil of Melissa officinalis (Lemon Balm) due to its terpenoid content, as a way to activate CB receptors, based on some preliminary research he has conducted.
In, 'Turned-Off Cannabinoid Receptor Turns on Colorectal Tumor Growth' published on
6. HOUSTON, Aug. 1, 2008 – New preclinical research shows that cannabinoid cell surface receptor CB1 plays a tumor-suppressing role in human colorectalcancer, scientists report in the Aug. 1 edition of the journal Cancer Research. CB1 is well-established for relieving pain and nausea, elevating mood and stimulating appetite by serving as a docking station for the cannabinoid group of signaling molecules. It now may serve as a new path for cancer prevention or treatment.
“We’ve found that CB1 expression is lost in most colorectal cancers, and when that happens a cancer-promoting protein is free to inhibit cell death,” said senior author Raymond DuBois, M.D., Ph.D., provost and executive vice president of The University of Texas M. D. Anderson Cancer Center. DuBois and collaborators from Vanderbilt-Ingram Cancer Center also show that CB1 expression can be restored with an existing drug, decitabine. They found that mice prone to developing intestinal tumors that also have functioning CB1 receptors develop fewer and smaller tumors when treated with a drug that mimics a cannabinoid receptor ligand. Ligands are molecules that function by binding to specific receptors. Agonists are synthetic molecules that mimic the action of a natural molecule.
“Potential application of cannabinoids as anti-tumor drugs is an exciting prospect, because cannabinoid agonists are being evaluated now to treat the side-effects of chemotherapy and radiation therapy,” DuBois said. “Turning CB1 back on and then treating with a cannabinoid agonist could provide a new approach to colorectal cancer treatment or prevention.”

In study entitled, "Loss of cannabinoid receptor 1 accelerates intestinal tumor growth," concluded, "In conclusion, our studies reveal the molecular mechanism by which cannabinoids inhibit tumor growth. We found that aberrant methylation of CB1 represents a clear mechanism for loss of expression in CRC. Using multiple approaches, we provide in vivo evidence demonstrating that endocannabinoid signaling via CB1 plays a key role in regulating intestinal tumor growth. Importantly, we elucidated the signaling pathway that mediates the pro-apoptotic effects of CB1. Moreover, our results may provide a rationale for the development of CB1 agonists that do not cross the blood-brain barrier for cancer prevention or treatment in combination with a demethylating agent.
Cannabinoids are a group of ligands that serve a variety of cell-signaling roles. Some are produced by the body internally (endocannabinoids). External cannabinoids include manmade versions and those present in plants, most famously the active ingredient in marijuana (THC).
Receptor shutdown by methylation
Endocannabinoid signaling is important to the normal functioning of the digestive system and has been shown to protect the colon against inflammation. Since chronic inflammation is a known risk factor for colorectal cancer, the researchers decided to look into the role of cannabinoid receptors in a mouse model of colon cancer.
“People have looked at cannabinoids in cancer earlier, mainly in cell culture experiments,” DuBois said. “The molecular mechanisms for loss of the receptor and its effect on cancer have not been previously shown.”
First, the team found that CB1 was largely absent in 18 of 19 human tumor specimens and in 9 of 10 colorectal cancer cell lines. Further experimentation showed that the gene that encodes the CB1 protein was not damaged, but shut down chemically by the attachment of methyl groups – a carbon atom surrounded by three hydrogen atoms – to the gene encoding CB1.

Nadine Bews regimen calls for 1/8 teaspoon of grocery store cinnamon (cinnamon cassia) taken daily with 1 oz minimum coca chocolate 90% butter, per 1 gram cannabis indica extract at night  for colon, stomach, breast cancers. Also, her regimen calls for 1-2 qt. Soda water with cranberry extract added to aid kidney function to move fluids. Another practioner suggests adding as much lemon juice as tolerable for aid in handling THC side effects.
To quote from a medical research paper here: here we find that the CB1 cannabinoid receptor is also effected by curcumin -The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists. We really cannot comprehend this report but have added for fellow researchers to determine the significance.

Be well and at peace ~ Holly

Thursday, February 26, 2015


Cannabis Paste For Dog Cancer

 Cannabis Paste Cure From Canna Cascadia

One of the most heartbreaking things we have ever witnessed was a beautiful dog with cancer, having already gone through chemotherapy, this poor dog was suffering so badly that we had to wonder, why would people put their loving pet through this misery and pain? Was it for the pet owner or the dog? It was a horrible sight to see!

We now know that there is an alternative to curing dog cancer and we are very grateful!

If you are hoping there is a better way to save your dog's life from cancer?
There are people around the world learning about Cannabis Paste as a New Cure for Dogs. Chemotherapy is as foolish and deadly to dogs as it is for humans. So what natural alternatives are there? 
Here are couple of the recommended steps. 
Please, contact us at Canna Cascadia for a free consultation.

1) Cannabis Paste added to the food
2) Eliminate Carbs
3) Add Curcumin, a derivative of the Indian spice Turmeric
4) Antioxidants (carotenoids, vitamin C and E, and Selenium
5) Throw out the horrible dog food and cook your own from scratch. 

An example of good dog food would be chicken, rice and vegetables, you may add the vitamins and spices to the homemade dog food.

Here is more exciting news for treating dogs with Cannabis Paste!

Cannabis advocates are no strangers to the social stigma that comes with using marijuana medically, so you can only imagine the number of eyebrows raised by the idea of treating an animal with hemp-derived cannabinoids. Even here in the progressive and cannabis friendly state of Oregon, the issue was met with a spectrum of reactions ranging from curious to outraged, confusing CBD consumption with “feeding an animal marijuana, this is just not the case.

If you are considering treating your pet with cannabinoids, you should do so under the guidance of a knowledgeable veterinarian. It’s clear that even medical professionals are still wary of marijuana and hemp-based medications for animals. If we are to carve out a good name for cannabis, it’s critical that we don’t allow any harm to come to our furry friends. These types of medicines are still in their infancy, however, it is truly exciting to witness a new frontier of therapeutic options for your dog’s improved quality of life and a cure. 

 There is also the exciting new Cannabis Paste treatment for Epileptic seizures for your  dog.

Normally, a Veterinarian will prescribe Phenobarbitol for Epileptic seizures, we all know that couldn't be good. 

For companion animals, even the American Veterinary Medical Association website carries testimonials favoring veterinary cannabis, in which caregivers attest to significant benefits in their animals, who were unresponsive or intolerant of mainstream pharmaceuticals.
Because of the higher toxicity of tetrahydrocannabinol (THC) in dogs compared to humans, many cannabis products sold for dogs list cannabidiol *(CBD) instead of THC as the main active ingredient. (THC is the substance in cannabis that typically makes human users high.)

*CBD, a non-psychoactive cannabinoid whose anti-epileptic properties were made widely known through the many stories of children finding relief from Epileptic seizures, and it  just so happened that companies were already putting out dog-specific CBD formulations derived from cannabis. We at Canna Cascadia for New Cure are proudly one of those companies.

CBD reduces pain, inflammation and anxiety as well as seizure activity. Research suggests that CBD has lower toxicity and higher tolerability than THC in both humans and non-humans.

Yes, People Are Giving Their Pets Medical Marijuana, even cats!

Photo illustration by Michael Mechanic based on a Flickr photo by Eva101.

Is it ever a good idea to get your dog or cat stoned? 
The answer depends on whether your pet could be classified as a medical marijuana patient.
Perhaps the nation's overtly 420-friendly vet, California veterinarian Doug Kramer has crowdsourced a slew of research on pot for pets. Through submissions to his website, and surveys distributed at pot dispensaries, he has amassed more than 500 case studies, the vast majority of them positive, he says. Most people use cannabis to treat their dogs and cats for pain, seizures, and inflammation stemming from arthritis. About 20 percent of phone calls to Kramer's office now come from other cannabis-curious vets.

"Anything people find effective when treating themselves, they are going to transfer to their pets," Kramer argues. He believes that lifting the veterinary taboo on pot would help pet owners make sure they're using cannabis safely. (He has published his own guide on the website) Ultimately, Kramer wants California and other states to allow the family dog to get its own pot card.
Kramer is one of the few veterinarians even willing to discuss using medical marijuana for pets. He points out that a slew of medical studies on the effects of pot have relied on rats and dogs as substitutes for humans, suggesting that "mammals have the same cannabinoid receptors as humans do" and "would benefit in the same ways."

But why stop there? He tells me of a woman who fed her horse cannabis-infused butter to treat it for laminitis, a foot disease that causes painful swelling. "She said it was like a new horse afterward!" 

 Photo illustration based on a photo by Their History

Of course, this is not how to give cannabis to a horse...ha!

We must now introduce our own Canna Cascadia mascot!
 Our Canna Cat 
Mr. Tibbs

Find Mr.Tibbs and Canna Cascadia on Pinterest!

Be well and happy ~ Todd and Holly

This blog post has excerpts from

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