Showing posts with label THC. Show all posts
Showing posts with label THC. Show all posts

Thursday, April 9, 2015

ACTIVATING CANNABINOID RECEPTORS

70 known Cannabinoids (8 showing)


FROM OUR PARTNERS AT NEW CURE
Edited and published by Right Reverend Gregory Karl Davis
Cannabinoid therapy appears to works marvelously for some, and yet others fail to respond.
Whilst it is critical to consider cannabinoid content as a factor in this (i.e. – Is there enough Cannabidiol (CBD) in your extract? Etc. Another mitigating detail lies within if ones cannabinoid receptors are activated or not.
Methylation has been proven to deactivate CB receptors, and this appears particularly prevalent within cancers of the stomach, colon1 and breast. If methylation can create such an unwanted and critical scenario during cannabinoid therapy, then those undergoing cannabinoid therapy should look to include demethylating2 agents into their regime.
These include; Green Tea, FeverFew and Annurca Apples3 Green Tea is particularly useful as it can also naturally create Anti-Angiogenesis4
Another area that should be explored is within the use of Phenolic Oils.
Phenols and Phenylpropanoids are compounds of carbon-ring molecules incorporating on isoprene unit. They are sometimes called hemiterpenes. There are dozens of varieties of phenylpropanoids. They are found in Clove (90%), Cassia (80%), Basil (75%), Cinnamon (73%), Oregano (60%), Anise (50%), and Peppermint (25%).
While they can create conditions where unfriendly viruses and bacteria cannot live, the most important function performed by phenylpropanoids is that they clean the receptor sites on the cells. Without clean receptor sites cells cannot communicate, and the body malfunctions, resulting in sickness.
David Stewart, PhD, DNM also suggests in his book 'The Chemistry of Essential Oils Made Simple’ – that phenolic oils can clean receptor sites.
Prof. Dr. Jürg Gertsch of the Institute of Biochemistry and Molecular Medicine, Switzerland conducted a brilliant research paper5 looking for Phytocannabinoids beyond cannabis.
Prof Jürg Gertsch was kind enough to suggest the essential oil of Melissa officinalis (Lemon Balm) due to its terpenoid content, as a way to activate CB receptors, based on some preliminary research he has conducted.
In, 'Turned-Off Cannabinoid Receptor Turns on Colorectal Tumor Growth' published on www.drugs.com
6. HOUSTON, Aug. 1, 2008 – New preclinical research shows that cannabinoid cell surface receptor CB1 plays a tumor-suppressing role in human colorectalcancer, scientists report in the Aug. 1 edition of the journal Cancer Research. CB1 is well-established for relieving pain and nausea, elevating mood and stimulating appetite by serving as a docking station for the cannabinoid group of signaling molecules. It now may serve as a new path for cancer prevention or treatment.
“We’ve found that CB1 expression is lost in most colorectal cancers, and when that happens a cancer-promoting protein is free to inhibit cell death,” said senior author Raymond DuBois, M.D., Ph.D., provost and executive vice president of The University of Texas M. D. Anderson Cancer Center. DuBois and collaborators from Vanderbilt-Ingram Cancer Center also show that CB1 expression can be restored with an existing drug, decitabine. They found that mice prone to developing intestinal tumors that also have functioning CB1 receptors develop fewer and smaller tumors when treated with a drug that mimics a cannabinoid receptor ligand. Ligands are molecules that function by binding to specific receptors. Agonists are synthetic molecules that mimic the action of a natural molecule.
“Potential application of cannabinoids as anti-tumor drugs is an exciting prospect, because cannabinoid agonists are being evaluated now to treat the side-effects of chemotherapy and radiation therapy,” DuBois said. “Turning CB1 back on and then treating with a cannabinoid agonist could provide a new approach to colorectal cancer treatment or prevention.”

In study entitled, "Loss of cannabinoid receptor 1 accelerates intestinal tumor growth," concluded, "In conclusion, our studies reveal the molecular mechanism by which cannabinoids inhibit tumor growth. We found that aberrant methylation of CB1 represents a clear mechanism for loss of expression in CRC. Using multiple approaches, we provide in vivo evidence demonstrating that endocannabinoid signaling via CB1 plays a key role in regulating intestinal tumor growth. Importantly, we elucidated the signaling pathway that mediates the pro-apoptotic effects of CB1. Moreover, our results may provide a rationale for the development of CB1 agonists that do not cross the blood-brain barrier for cancer prevention or treatment in combination with a demethylating agent.
Cannabinoids are a group of ligands that serve a variety of cell-signaling roles. Some are produced by the body internally (endocannabinoids). External cannabinoids include manmade versions and those present in plants, most famously the active ingredient in marijuana (THC).
Receptor shutdown by methylation
Endocannabinoid signaling is important to the normal functioning of the digestive system and has been shown to protect the colon against inflammation. Since chronic inflammation is a known risk factor for colorectal cancer, the researchers decided to look into the role of cannabinoid receptors in a mouse model of colon cancer.
“People have looked at cannabinoids in cancer earlier, mainly in cell culture experiments,” DuBois said. “The molecular mechanisms for loss of the receptor and its effect on cancer have not been previously shown.”
First, the team found that CB1 was largely absent in 18 of 19 human tumor specimens and in 9 of 10 colorectal cancer cell lines. Further experimentation showed that the gene that encodes the CB1 protein was not damaged, but shut down chemically by the attachment of methyl groups – a carbon atom surrounded by three hydrogen atoms – to the gene encoding CB1.

Nadine Bews regimen calls for 1/8 teaspoon of grocery store cinnamon (cinnamon cassia) taken daily with 1 oz minimum coca chocolate 90% butter, per 1 gram cannabis indica extract at night  for colon, stomach, breast cancers. Also, her regimen calls for 1-2 qt. Soda water with cranberry extract added to aid kidney function to move fluids. Another practioner suggests adding as much lemon juice as tolerable for aid in handling THC side effects.
To quote from a medical research paper here: here we find that the CB1 cannabinoid receptor is also effected by curcumin -The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists. We really cannot comprehend this report but have added for fellow researchers to determine the significance. http://www.ncbi.nlm.nih.gov/pubmed/19359525


Be well and at peace ~ Holly

Wednesday, March 18, 2015

LISTEN TO CANNA CAT FOR NEW CURE

CANNA CAT

Anyone Over 21 Can Get Cannabis Paste! In states with legalized medical use. In some states, it may require a Patient Medical Marijuana Card or Caretaker Card. 
If you own a dispensary or clinic
Contact us for wholesale opportunities.

By law New Cure has found a loophole, so we at CANNA CASCADIA can provide healing and hope for you, allowing anyone (over 21) anywhere to obtain the Cannabis Paste.This means any strain of cannabis or hemp. THC free or not. High in CBD or not, Cannabis Paste is the most effective form of Cannabis.

Your medical records are NOT required. Anyone who wants the paste must consult with our staff via phone and proof of age will be required.

Even though THC is frowned upon or not legal in many states when given to children, it is hands down far more effective in reducing seizures and fighting off cancer and other illnesses and so much better and more compassionate than chemotherapy and radiation! We want to build the body up not tear it down with dangerous chemicals, chemo is poison. 

CBD is amazing by itself, but THC and CBD together are the far better choice. So if you are contemplating and are not sure about giving or taking a high THC strain, you might want to weigh the facts that in most cases pharmaceutical drugs are very damaging and cause layers of mental and physical damage. It's a choice you have to make. New Cure has expressed its opinion but is NOT prescribing or recommending high-THC strains to children due to legal reasons. We wish you the best in this tough decision. You don't have to get anyone high/stoned in order for the seizures to reduce or stop. It takes a small amount of the paste to decrease the seizures or fight off cancer or Lyme disease. The point is the majority of people taking drugs like Keppra experience horrible side effects, the crazy thing is you never hear negative stories about Cannabis, more doctors today are endorsing and prescribing Cannabis products for their patients, as more and more success stories from patients arrive and scientists continue to tout the benefits and healing properties of Cannabis. We will all see Cannabis as a medicine become more mainstream.
We have the testimonials to prove the positive results that Canna Paste offers!

In regard to cancer -


It is important to maintain a super healthy green diet! Don't expect to survive by Cannabis only. Yes, Cannabis Paste is amazing and can change a person's life but you need to correct the heath problem. We have recently learned that if your cancer is candida based that diatomaceous earth works best for ridding the body of candida and parasites, this way cannabis will have a clear pathway to the body's receptors.

Why did you get Cancer? Here is a great article to look at - Click Here

For a free and friendly consultation, we are happy to help you acquire Canna Paste.

Our purpose is to help and heal you!
We will get back to you within 48 hours -

SWEET CANNABIS LOVE

#cannacascadia #cannabispaste #cannabiscures

Monday, February 16, 2015

WHY CANNABIS PASTE WORKS




Science stuff about the active ingredient in marijuana
amcs-mmj.com
Color enhanced image of electron microscopic view of marijuana trichomes.

The purpose of my blog post today is to inform you as to "why Cannabis Paste works", more specifically, why does Cannabis Paste work on so many different diseases and ailments?

The above question is closer to what I wanted to say in my post title, but that was obviously too long. So let's get right down to it, we now have more and more science and scientists exclaiming that cannabis is gaining fast ground on curing and treating the likes of Cancer, Epilepsy, pain management, inflammatory diseases, Diabetes; Cannabis also treats Parkinson's symptoms and Lyme disease, the list goes on, you would think we were dealing with big Pharma's new cure-all wonder drug! But no, we are talking about something that has been around for thousands of years, and used by civilization for just as long, in other words, the establishment cannot hide the truth about cannabis from the people any longer, so with a couple of google searches about CBDs and THC and an open mind, most reasonable people will see for themselves that the amazing symbiotic relationship that humans have with the cannabis plant is not really 'new' news. 

Additionally, the process for making Cannabis Paste allows for maintaining life-saving CBD and THC levels that act on key receptors throughout the body, beginning a whole new natural chain reaction of healing, that your body has surprisingly been programmed to work harmoniously our body's physiology, a with one plant, Cannabis!


Below is a video that explains the science. I promise you will be riveted to your seat!



What if Cannabis Cured Cancer explains how we are all born with a form of Cannabis already in our bodies, and when consumed, the Endocannabinoids inside us, along with any Cannabinoids we ingest, fit together like a key in a lock, unlocking special processes. Thereby promoting the death of cancer cells without harming the body's healthy cells using Programmed Cell Death but not limited to Programmed Cell Death. A powerful and eye-opening film about the future of cannabis, and perhaps even the future of medicine.


Narrated by Emmy-winning actor Peter Coyote.




So, now I hope that most can agree that cannabis is beneficial to us on many levels. which now brings me to my analogy of comparing the benefits of using Cannabis Paste, as a whole plant, to the benefits consuming whole raw fruits and vegetables, not unlike the infamous Jack LaLanne way, who used whole fruits and vegetables, seeds, stalks and all in his healthy juices.
Mr. LaLanne understood the benefits of raw and whole, New Cure uses the same philosophy and the results are in the testimony of the patients who use Cannabis Paste as a cure or treatment.


Jack LaLanne with his wife, at 95 years young

 Well, that's my story for the day. I hope I have given you a reason to think about cannabis in a new way, or at least added to your knowledge base.
Be Well - Todd

At Canna Cascadia, we wish you hope and healing. You may contact us at our website for information on obtaining medical cannabis paste.



  

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